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Posted by Larry Grunfeld, MD on July 31, 19100 at 13:11:05:

In Reply to: QUESTIONS FOR DOCTOR, PLEASE posted by Roseanne on July 29, 19100 at 08:07:27:

Therapy in women who are over 45 is extremely challenging. Cycles rarely respond the way they do in younger women. You need support, while at the same time honest appraisals of your response to therapy. Unfortunately, standard measures of egg reserve are less reassuring at your age.

While I cannot answer your specific question about your chances of conception, I would like to recommend that you attend Pat Mendell's seminar on ovum donation (sponsored by the AIA). Nearly all the women in this group are grapelling with the same issues as you.

Hoping that your therapy is succesful.

Larry Grunfeld, MD

: I just turned 46 and have tried Clomid (a high dosage, which produced two eggs), Gonol-F (8 amps/day) a few months later, and Pergonal (8amps/day) just recently. I did not respond to either Gonol-F or Pergonal. My questions are:

: 1. How can I optimize my chances for a better response to medication? (I can't believe I don't have at least a few decent eggs left!)

: 2. Is it possible that I was overmedicated?

: 3. Should fertility-drug treatments be given consecutively, or am I wise to wait a month or two between each?

: 4. My RE (who is honest about my slim chances) has put me on BCPs for two months, before we try again. How can this help?

: Time is a wasting, and I eventually have to put closure to this. For now, though, I need to give it all I have. Thank you in advance for your kind advice.

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