Posted by Serena Chen, MD on July 12, 19100 at 09:54:01:
In Reply to: Q for Docs RE: High Responder Protocols posted by Liz on July 12, 19100 at 08:25:32:
Dear Liz:
There are many different protocols available. Sometimes it is hard to predict which one will work best for an individual person. It is particularly difficult to get just the right dose for high responders. BCP's can be helpful as well as increasing your dose of lupron. Since that did not work in your particular case, it may be reasonable to consider lowering the dose of your gonadotropins. If you have polycystic ovaries, you may benefit from metformin. There are not many studies done yet. You should discuss with your MD whether or not s/he thinks metformin would be helpful in your particular case.
Good Luck,
Serena Chen
: Age = 27
: Dx = Male Factor
: My first IVF cycle yielded 19 eggs but well over half were immature, so there was only one embryo left for transfer. For the 2nd cycle, the doctor recommended a high responder protocol: bcp's for about 4 weeks, overlapped for one week with Lupron (20IU's). Well, this cycle yielded the same number of eggs, but even less were mature. I also stimmed just as fast in the 2nd cycle as I did in the first -- retrieval was only 9 days after began stims.
: My question is: are there more aggressive high resonder protocols than the one I was on? Also, is this problem related to my age, and is there any benefit to waiting a year or two until my ovaries are less hyper-active?